بهینه‌سازی فرایند اکسیداسیون فتوشیمیایی دگزامتازون بر پایه رادیکال‌های سولفات به روش سطح پاسخ

نویسندگان

1 دانشجوی دکتری مهندسی آب و فاضلاب، دانشکده محیط زیست، دانشگاه تهران. تهران، ایران.

2 گروه مهندسی محیط زیست، دانشکده محیط زیست، دانشگاه تهران، تهران، ایران.

3 گروه مهندسی محیط زیست، دانشکده محیط زیست، دانشگاه تهران، تهران، ایران

10.22125/iwe.2023.173337

چکیده

دگزامتازون از پرمصرف­ترین گلوکوکورتیکواستروئیدها در مراکز درمانی به شمار می‌رود که با توجه به عدم کارایی روش­های تصفیه متداول در حذف آن از فاضلاب، امکان­سنجی کاربرد رادیکال سولفات جهت حذف مناسب این آلاینده از محلول­های آبی ضرورت دارد. هدف از انجام این مطالعه، بررسی حذف داروی دگزامتازون از محلول­های آبی توسط رادیکال سولفات تحت تابش پرتو فرابنفش (UV/S2O8-2) با استفاده از روش سطح پاسخ (RSM) می­باشد. میزان حذف دگزامتازون با بررسی تاثیر متغیرهای pH بین 9-3، پرسولفات (mM/L 5- 5/0)، غلظت اولیه دگزامتازون (mg/L 10- 2) و زمان واکنش (10 تا 60 دقیقه) مورد بررسی قرار گرفت. غلظت دگزامتازون با استفاده از دستگاه کروماتوگرافی مایع با عملکرد بالا (HPLC) در طول موج 213 نانومتر سنجش شد. نتایج نشان داد فرایند  UV/S2O8-2در حذف کامل دگزامتازون موثر است، به­نحوی که با کاهش pH و غلظت دگزامتازون اولیه و همچنین با افزایش غلظت پرسولفات و زمان تماس، راندمان حذف دگزامتازون افزایش می­یابد. نتایج این مطالعه نشان داد می­توان با استفاده از مدل آماری سطح پاسخ، در تعداد معینی از آزمایش­ها، فرایند UV/S2O8-2  را بهینه­سازی نمود. حذف دگزامتازون در شرایط بهینه pH (7/7)، غلظت پرسولفات (mM/L 7/2)، غلظت اولیه دگزامتازون (mg/L 2/5) و زمان واکنش 34 دقیقه، 100 درصد می­باشد. با توجه به پایداری و توانایی اکسیداسیون بالای رادیکال­های سولفات (SO4-.)، پیشنهاد می­شود که از فرایند  UV/S2O8-2 جهت حذف دگزامتازون از محلول­های آبی استفاده گردد.
 
 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Optimization of Dexamethasone Photochemical Oxidation Process Based on Sulfate Radicals using Response Surface Methodology

نویسندگان [English]

  • Kamyar Arman 1
  • Majid Baghdadi 2
  • Alireza Pardakhti 3
1 PhD student in Water and Wastewater Engineering, Faculty of Environment, University of Tehran. Tehran, Iran.
2 Department of Environmental Engineering, Faculty of Environment, College of Engineering, University of Tehran, Tehran, Iran.
3 , Department of Environmental Engineering, Faculty of Environment, College of Engineering, University of Tehran, Tehran, Iran
چکیده [English]

Dexamethasone is one of the most widely used glucocorticosteroids in medical centers. Due to the inefficiency of conventional treatment methods in its removal from wastewater, it is necessary to evaluate the use of sulfate radicals to properly remove this contaminant from aqueous solutions. The aim of this study was to investigate the removal of dexamethasone from aqueous solutions by sulfate radical under ultraviolet irradiation (UV/S2O8-2) using the Response Surface Methodology (RSM). Dexamethasone removal efficiency in this method by investigating the effect of pH variables between 3 to 9, persulfate (0.5-5 mM/L), initial concentration of dexamethasone (2-10 mg/L) and reaction time (10 to 60 minutes) Was investigated. Dexamethasone concentrations were measured using a high-performance liquid chromatography (HPLC) at 213 nm. The results showed that the UV/S2O8-2 process is effective in the complete removal of dexamethasone, so that by decreasing the pH and concentration of the initial dexamethasone as well as by increasing the concentration of persulfate and reaction time, the removal efficiency of dexamethasone increases. The results of this study showed that the UV/S2O8-2 process can be optimized in a certain number of experiments using the response surface methodology. Dexamethasone removal under optimal conditions of pH (7.7), persulfate concentration (2.7 mM/L), initial concentration of dexamethasone (5.2 mg/L) and reaction time of 34 minutes is 100 %. Due to the stability and high oxidation ability of sulfate radicals (SO4-.), It is recommended to use UV/S2O8-2 process to remove dexamethasone from aqueous solutions.
 

کلیدواژه‌ها [English]

  • Aqueous solutions
  • Dexamethasone
  • Photochemical
  • Response surface methodology
  • Sulfate radical

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